PKR INHIBITOR
PKR-IN-C16
CAS: 608512-97-6
Molecular Formula: C13H8N4OS
PKR INHIBITOR - Names and Identifiers
PKR INHIBITOR - Physico-chemical Properties
| Molecular Formula | C13H8N4OS |
| Molar Mass | 268.29 |
| Density | 1.604±0.06 g/cm3(Predicted) |
| Boling Point | 674.6±55.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| Appearance | Orange to orange brown solid |
| Color | yellow to orange-brown |
| pKa | 10.20±0.20(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchsae as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| Use | PKR-IN-C16 are specific protein kinase (PKR) inhibitors. PKR-IN-C16 can inhibit the autophosphorylation of PKR, and the translation blockade induced by PKR in primary neuron cell culture can be relieved by PKR-IN-C16. C16, also known as GW-506033X or PKR Inhibitor. C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. GW-506033X protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. PKR inhibitor C16 binds efficiently with human microtubule affinity-regulating kinase 4. |
PKR INHIBITOR - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
PKR INHIBITOR - Reference
| Reference Show more | 1: Naz F, Shahbaaz M, Khan S, Bisetty K, Islam A, Ahmad F, Hassan MI. PKR-inhibitor binds efficiently with human microtubule affinity-regulating kinase 4. J Mol Graph Model. 2015 Nov;62:245-52. doi: 10.1016/j.jmgm.2015.10.009. PubMed PMID: 26519933. 2: Tronel C, Page G, Bodard S, Chalon S, Antier D. The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan;64:73-83. doi: 10.1016/j.neuint.2013.10.012. PubMed PMID: 24211709. 3: Clerzius G, Shaw E, Daher A, Burugu S, Gélinas JF, Ear T, Sinck L, Routy JP, Mouland AJ, Patel RC, Gatignol A. The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication. Retrovirology. 2013 Sep 11;10:96. doi: 10.1186/1742-4690-10-96. PubMed PMID: 24020926; PubMed Central PMCID: PMC3848765. 4: Bilgin DD, Liu Y, Schiff M, Dinesh-Kumar SP. P58(IPK), a plant ortholog of double-stranded RNA-dependent protein kinase PKR inhibitor, functions in viral pathogenesis. Dev Cell. 2003 May;4(5):651-61. PubMed PMID: 12737801. 5: Gerotto M, Dal Pero F, Pontisso P, Noventa F, Gatta A, Alberti A. Two PKR inhibitor HCV proteins correlate with early but not sustained response to interferon. Gastroenterology. 2000 Dec;119(6):1649-55. PubMed PMID: 11113086. |
PKR INHIBITOR - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.727 ml | 18.637 ml | 37.273 ml |
| 5 mM | 0.745 ml | 3.727 ml | 7.455 ml |
| 10 mM | 0.373 ml | 1.864 ml | 3.727 ml |
| 5 mM | 0.075 ml | 0.373 ml | 0.745 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: PKR-IN-C16 Visit Supplier Webpage Request for quotationCAS: 608512-97-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: PKR-IN-C16 Visit Supplier Webpage Request for quotationCAS: 608512-97-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: PKR-IN-C16 Visit Supplier Webpage Request for quotationCAS: 608512-97-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
PKR INHIBITOR
L-ORNITINE MONOCHLORHYDRATE
5-氯苯并-2,1,3噻二唑
m-Fluorobenzenethiol
溴二氟苯乙酸 2-丙烯基酯
Methylene Chloride (13C)
3-Hydrazono-1-methyl-2,3-dihydro-1h-pyrazole(hydrochloride)
1-Imidazolidineacetic acid, 3-[(2,6-dichlorophenyl)methyl]-2,4,5-trioxo-, ethyl ester
DIFLUMETORIM STANDARD
4-chlorophenyl 1-{1-[(2-chlorophenyl)sulfonyl]-1H-pyrazol-5-yl}-2-phenylvinyl ether
L-ORNITINE MONOCHLORHYDRATE
5-氯苯并-2,1,3噻二唑
m-Fluorobenzenethiol
溴二氟苯乙酸 2-丙烯基酯
Methylene Chloride (13C)
3-Hydrazono-1-methyl-2,3-dihydro-1h-pyrazole(hydrochloride)
1-Imidazolidineacetic acid, 3-[(2,6-dichlorophenyl)methyl]-2,4,5-trioxo-, ethyl ester
DIFLUMETORIM STANDARD
4-chlorophenyl 1-{1-[(2-chlorophenyl)sulfonyl]-1H-pyrazol-5-yl}-2-phenylvinyl ether